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Anticonvulsants, Phenytoin
Dosage form:
Tablet
Strength:
50mg (Infatab)
Indications/Special comments:
Generalized tonic-clonic seizures; partial seizures; status epilepticus
Dosage Administration:
Generalized tonic-clonic seizures, partial seizures: Oral: Adult: initially 3 - 4mg/kg daily (as a single dose or in 2 divided doses), increased gradually at intervals of 2 weeks as necessary (with plasma- phenytoin concentration monitoring); usual dose 200 – 500mg daily; Child: initially 5mg/kg daily in 2 divided doses; usual dose range 4 - 8mg/kg daily (maximum 300mg). Note. Plasma concentration for optimum response 10 - 20mg/litre (40 - 80 micromol/litre)
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Anticonvulsants, Phenytoin
Dosage form:
Suspension
Strength:
125mg/5ml
Indications/Special comments:
Generalized tonic-clonic seizures; partial seizures; status epilepticus
Dosage Administration:
Generalized tonic-clonic seizures, partial seizures: Oral: Adult: initially 3 - 4mg/kg daily (as a single dose or in 2 divided doses), increased gradually at intervals of 2 weeks as necessary (with plasma- phenytoin concentration monitoring); usual dose 200 – 500mg daily; Child: initially 5mg/kg daily in 2 divided doses; usual dose range 4 - 8mg/kg daily (maximum 300mg). Note. Plasma concentration for optimum response 10 - 20mg/litre (40 - 80 micromol/litre)
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Anticonvulsants, Phenytoin
Dosage form:
Powder for Injection
Strength:
50mg/ml in vial
Indications/Special comments:
Generalized tonic-clonic seizures; partial seizures; status epilepticus
Dosage Administration:
Status epilepticus: Slow IV injection or by IV infusion (with blood pressure and ECG monitoring): Adult: 15mg/kg at rate of not more than 50mg/minute, as a loading dose; maintenance doses of about 100mg by mouth or by slow IV injection should be given thereafter at intervals of 6 - 8 hours, monitored by measurement of plasma concentrations; rates and dose reduced according to weight. Child: 15mg/kg as loading dose at rate of 1mg/kg/minute (not exceeding 50mg/minute). Neonate: 15 - 20mg/kg as a loading dose at rate of 1 - 3mg/kg/minute.
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Anticonvulsants, Phenytoin
Dosage form:
Capsule
Strength:
100mg
Indications/Special comments:
Generalized tonic-clonic seizures; partial seizures; status epilepticus
Dosage Administration:
Generalized tonic-clonic seizures, partial seizures: Oral: Adult: initially 3 - 4mg/kg daily (as a single dose or in 2 divided doses), increased gradually at intervals of 2 weeks as necessary (with plasma- phenytoin concentration monitoring); usual dose 200 – 500mg daily; Child: initially 5mg/kg daily in 2 divided doses; usual dose range 4 - 8mg/kg daily (maximum 300mg). Note. Plasma concentration for optimum response 10 - 20mg/litre (40 - 80 micromol/litre)
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Antibacterials, Pyrazinamide
Dosage form:
Tablet
Strength:
500mg
Indications/Special comments:
Tuberculosis, in combination with other drugs.
Dosage Administration:
Tuberculosis (initial phase of combination therapy: Oral: Adult and child: 25mg/kg daily or 35mg/kg 3 times weekly.
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Antibacterials, Polymixin B
Dosage form:
Injection
Strength:
0.5MU
Indications/Special comments:
Treatment of acute infections caused by susceptible strains of Pseudomonas aerginosa, reserved for life threatening infections caused by organisms resistant to preferred drugs i.e. Pseudomonal menigitis – intrathecal administration
Dosage Administration:
Infants < 2 years: IM: Up to 40,000 units/kg/day divided every 6 hours not usually recommended due to pain at injection site. IV: up to 40,000 units/kg/day divided every 12 hours; Intrathecal: 20,000 units per day for 3 - 4 days then 25,000 units every other day for at least 2 weeks after CSF cultures are negative and returns to normal limits. Children> 2years, Adolescence and adults: IM: 25,000 – 30,000 units/kg/day divided every 4 - 6 hours not routinely recommended because of pain at site; IV: 15,000 - 25,000 units/kg/day given evey 12 hours. Intrathecal: 50,000 units daily for 3 - 4 days then every other day for at least 2 weeks after CSF cultures are negative and CSF returns to normal limits. Total daily dose should not exceed 2,000,000 units. Bladder irrigation: Continuous irrigation or rinse in urinary bladder for up to 10 days using 20mg (equivalent of 200,000 units) added to 1L of normal saline. Usually no more than 1L of irrigant is used daily unless urine flow rate is high administration rate is adjusted to patients output. Topical irrigation or solution: 500,000 units per liter of normal saline maximum total daily dose should not exceed 2 million units in adults.
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Antibacterials, Piperacillin Tazobactum
Dosage form:
Injection
Strength:
4.5g, 3.375g in vial
Indications/Special comments:
Hospital-acquired pneumonia. Septicaemia. Complicated infections involving the urinary-tract or skin and soft tissues. Infections in neutropenic patients
Dosage Administration:
Hospital-acquired pneumonia; Septicaemia; Complicated infections involving the urinary-tract or skin and soft tissues: By intravenous infusion: Adult: 4.5g every 8 hours; increased if necessary to 4.5g every 6 hours, increased frequency may be used for severe infections. Infections in neutropenic patients: By intravenous infusion: Adult: 4.5g every 6 hours
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Antibacterials, Penicillin G Sodium crystalline
Dosage form:
Injection
Strength:
1 MU, 10MU, 20MU in vial
Indications/Special comments:
Throat infections, pneumonia, otitis media, lyme disease in children; streptococcal endocarditis; meningococcal disease; necrotizing enterocolitis, necrotizing fascitis; leptospirosis, neurosyphilis, anthrax; actinomycosis; brain abscess; gas gangrene; cellulitis; osteomyelitis
Dosage Administration:
Mild to moderate infections due to sensitive organisms: IM or slow IV injection or infusion: Adult: 0.6 – 2.4g daily in 2 – 4 divided doses, with higher doses in severe infections and duration of treatment depending on disease; Neonate: 50mg/kg daily in 2 divided doses; Infant 1 to 4 weeks: 75mg/kg daily in 3 divided doses; Child 1 month to 12 years: 100mg/kg daily in 4 divided doses, with higher doses in severe infections.see package insert for more dosing regimes
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Antibacterials, Penicillin G Benzathine
Dosage form:
Injection
Strength:
0.6, 1.2, 2.4 million IU in vial.
Indications/Special comments:
Streptococcal pharyngitis; diphtheria carrier state; syphilis and other treponemal infections (yaws, pinta, bejel); rheumatic fever prophylaxis.
Dosage Administration:
Deep IM injection: Streptococcal pharyngitis; primary prophylaxis of rheumatic fever: Adult and Child over 30 Kg body-weight: 900mg as a single dose; Child under 30 Kg body – weight: 450 – 675mg as a single dose. Secondary prophylaxis of rheumatic fever: Adult and Child over 30 Kg body-weight: 900mg once every 3 – 4 weeks; Child under 30 Kg body-weight: 450mg once every 3 – 4 weeks. Early syphilis: Adult: 1.8g as a single dose, divided between 2 sites. Late syphilis: Adult: 1.8g divided between two sites, once weekly for 3 consecutive weeks. Congenital syphilis (where no evidence of CSF involvement): Child up to 2 years: 37.5mg/kg as a single dose. Yaws, Pinta, and bejel: Adult: 900mg as a single dose; Child: 450mg as a single dose. Note: Reconstitution and Administration. According to manufacturer’s directions
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Analgesics, Pregablin
Dosage form:
Capsule
Strength:
75mg, 150mg
Indications/Special comments:
Peripheral and central neuropathic pain. Adjunctive therapy for focal seizures with or without secondary generalisation. Generalised anxiety disorder.
Dosage Administration:
Peripheral and central neuropathic pain: By mouth: Adult: Initially, 150mg daily in 2 – 3 divided doses, then increased if necessary to 300mg daily in 2 – 3 divided doses, dose to be increased after 3 – 7 days, then increased if necessary up to 600mg daily in 2 –3 divided doses, dose to be increased after 7 days. Adjunctive therapy for focal seizures with or without secondary generalization: By mouth: Adult: Initially 25mg twice daily, then increased in steps of 50mg daily, dose to be increased at 7 day intervals, increased to 300mg daily in 2 – 3 divided doses for 7 days, then increased if necessary up to 600 mg daily in 2 – 3 divided doses. Generalized anxiety disorder: By mouth: Adult: Initially, 150mg daily in 2–3 divided doses, then increased in steps of 150mg daily if required, dose to be increased at 7 day intervals, increased if necessary up to 600mg daily in 2 – 3 divided doses.
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Important notices
Tender for Provision of Cleaning Services at GBHS (Grand Bahama)
Tender for the Provision of Security Guard Services at the Sandilands Rehab Centre
PHA Announces the Appointment of Dr Francis Williams as MCOS PMH