• Cholinergic and Anticholinesterase Agents, Pyridostigmine Bromide
    Dosage form: Tablet
    Strength: 60mg, 180mg (sustained release
    Indications/Special comments: Myasthenia gravis
    Dosage Administration: Initially 200–400 mg daily in divided doses until the patient becomes euthyroid, then reduced to 50–150 mg daily in divided doses, initial dose should be gradually reduced to the maintenance dose.
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  • Cardiovascular Drugs, Propranolol
    Dosage form: Tablet
    Strength: 10mg, 40mg, 60mg, 80mg
    Indications/Special comments: Cardiac arrhythmia, myocardial infarction, angina pectoris, hypertension, adjunct in the management of thyrotoxicosis, migraine prophylaxis.
    Dosage Administration: Tachyarrhythmias: Oral: Adult: 10 - 30mg/dose every 6 - 8 hours. Child: Initial: 0.5 - 1mg/kg/day in divided doses every 6 - 8 hours; titrate dosage upward every 3 - 7 days; usual dose: 2 - 6mg/kg/day; higher doses may be needed; do not exceed 16mg/kg/day or 60mg/day. Hypertension: Oral: 80mg twice daily increased at weekly intervals as required, maintenance 160 - 320mg daily.
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  • Cardiovascular Drugs, Propranolol
    Dosage form: Injection
    Strength: 1mg/ml
    Indications/Special comments: Cardiac arrhythmia, myocardial infarction, angina pectoris, hypertension, adjunct in the management of thyrotoxicosis, migraine prophylaxis.
    Dosage Administration: Tachyarrithmias: IV: Adult: 1mg/dose slow IV injection; repeat every 5 minutes up to a total of 5mg. Child: 0.01 - 0.1mg/kg/dose slow IV injection over 10 minutes; maximum dose: 1mg for infants; 3mg for children. Hypertension: IV injection: 1.3mg administered at a rate not to exceed 1mg/minute, repeated after two minutes and again after four hours if necessary.
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  • Cardiovascular Drugs, Procainamide Hydrochloride
    Dosage form: Tablet (SR)
    Strength: 250mg
    Indications/Special comments: Severe ventricular arrhythmias, especially those resistant to lidocaine or those appearing after myocardial infarction; atrial tachycardia, atrial fibrillation; maintenance of sinus rhythm after cardioversion of atrial fibrillation.
    Dosage Administration: Adult: Ventricular arrhythmias: Oral: up to 50mg/kg daily in divided doses every 3 - 6 hours. Atrial arrhythmias higher doses may be required. Child: Oral: 40 - 60 mg/kg/day divided every 4 - 6 hours.
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  • Cardiovascular Drugs, Procainamide Hydrochloride
    Dosage form: Injection
    Strength: 100mg/ml
    Indications/Special comments: Severe ventricular arrhythmias, especially those resistant to lidocaine or those appearing after myocardial infarction; atrial tachycardia, atrial fibrillation; maintenance of sinus rhythm after cardioversion of atrial fibrillation.
    Dosage Administration: IV injection: 25 - 50mg over one-minute period then repeated every 5 minutes until the arrhythmia is controlled, hypotension results, or the QRS complex is prolonged more than 50%. Child: I.V: 3 - 6mg/kg every 10 - 30 minutes (maximum 100mg/dose, then 0.02 - 0.08mg/kg/minutes).
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  • Cardiovascular Drugs, Prazosin
    Dosage form: Capsule
    Strength: 1mg, 2mg, 5mg
    Indications/Special comments: Hypertension, congestive heart failure, Raynaud's syndrome (but efficacy not established, benign prostatic hyperplasia.
    Dosage Administration: Hypertension: By mouth: Adult: Initially, 500 micrograms 2 – 3 times a day for 3 – 7 days, the initial dose should be taken on retiring to bed at night to avoid collapse, increased to 1mg 2 – 3 times a day for a further 3 – 7 days, then increased if necessary up to 20mg daily in divided doses. Congestive heart failure (rarely used): By mouth: Adult: 500 micrograms 2 – 4 times a day, initial dose to be taken at bedtime, then increased to 4mg daily in divided doses; maintenance 4 –20mg daily in divided doses.Raynaud's syndrome (but efficacy not established): By mouth: Adult: Initially, 500 micrograms twice daily, initial dose to be taken at bedtime, dose may be increased after 3 – 7 days, and then increased if necessary to 1 – 2mg twice daily. Benign prostatic hyperplasia: By mouth: Adult: Initially, 500 micrograms twice daily for 3 – 7 days, subsequent doses should be adjusted according to response, maintenance 2mg twice daily, initiate with lowest possible dose in elderly patients.
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  • Cardiovascular Drugs, Pravastatin Sodium
    Dosage form: Tablet
    Strength: 10mg, 20mg, 40mg, 80mg
    Indications/Special comments: Adjunct to diet for primary hypercholesterolaemia or combined (mixed) hyperlipidaemias in part prevention of cardiovascular events in patients with previous myocardial infarction or unstable angina. Adjunct to diet to prevent cardiovascular events in patients with hypercholesterolaemia. Patients who have not responded adequately to dietary control. Reduction of hyperlipidaemia in patients receiving immunosuppressive therapy following solid-organ transplantation
    Dosage Administration: Adjunct to diet for primary hypercholesterolaemia or combined (mixed) hyperlipidaemias in patients who have not responded adequately to dietary control. By mouth: Adult: 10 – 40mg daily, dose to be taken at night, dose to be adjusted at intervals of at least 4 weeks. Prevention of cardiovascular events in patients with previous myocardial infarction or unstable angina. Adjunct to diet to prevent cardiovascular events in patients with hypercholesterolaemia; By mouth: Adult: 40mg daily, dose to be taken at night. Reduction of hyperlipidaemia in patients receiving immunosuppressive therapy following solid-organ transplantation. By mouth: Adult: Initially. 20mg daily, then increased if necessary up to 40mg daily, dose to be taken at night, close medical supervision is required if dose is increased to maximum dose.
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  • Cardiovascular Drugs, Phenylephrine Hydrochloride
    Dosage form: Injection
    Strength: 10mg/ml
    Indications/Special comments: Treatment of vascular failure, unresponsive to adequate fluid volume replacement, in shock, shock like states, drug induced hypotension, or hypersensitivity.
    Dosage Administration: Treatment of vascular failure, unresponsive to adequate fluid volume replacement, in shock, shock like states, drug induced hypotension, or hypersensitivity.
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  • Cardiovascular Drugs, Phentolamine Mesylate
    Dosage form: Injection
    Strength: 10mg/ml
    Indications/Special comments: Hypertensive episodes due to phaeochromocytoma e.g. during surgery
    Dosage Administration: Hypertensive episodes due to phaeochromocytoma e.g. during surgery. By intravenous injection: Adult 2 – 5mg, repeated if necessary. Diagnosis of phaeochromocytoma: Phentolamine blocking test. The test is most reliable in detecting pheochromocytoma in patients with sustained hypertension and least reliable in those with paroxysmal hypertension. False-positive tests may occur in patients with hypertension without pheochromocytoma. Children: IM: 3mg, IV: 1mg. Adults: IM or IV: 5mg.
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  • Cardiovascular Drugs, Perindopril Arginine + Indapamide
    Dosage form: Tablet
    Strength: 2.5+0.625mg; 5+1.25mg; 10+2.5mg
    Indications/Special comments: Hypertension treatment when perindopril alone does not control
    Dosage Administration: Hypertension: Adults: Oral: Initial: Perindopril 3.5mg/amlodipine 2.5 mg once daily; adjust dose to response in 7 to 14 day intervals; maximum dose: perindopril 14mg/amlodipine 10mg once daily.Note: Not recommended in patients >65 years of age
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