• Respiratory Drugs, Oseltamivir
    Dosage form: Suspension
    Strength: Suspension
    Indications/Special comments: Prevention of influenza. Treatment of influenza
    Dosage Administration: Treatment of influenza: By mouth: Child 1 – 11 months: 3mg/kg twice daily for 5 days. Child 1 – 12 years (body-weight 10 – 15kg): 30mg twice daily for 5 days. Child 1 – 12 years (body-weight 15 – 23kg): 45mg twice daily for 5 days. Child 1 – 12 years (body-weight 23 – 40kg): 60mg twice daily for 5 days. Child 1 – 12 years (body-weight 40kg and above): 75mg twice daily for 5 days. Child 13 – 17 years: 75mg twice daily for 5 days. Adult: 75mg twice daily for 5 days.
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  • Respiratory Drugs, Oseltamivir
    Dosage form: Capsule
    Strength: 100mg
    Indications/Special comments: Prevention of influenza. Treatment of influenza
    Dosage Administration: Prevention of influenza: By mouth: Child 1 – 11 months: 3mg/kg once daily for 10 days for post-exposure prophylaxis. Child 1 – 12 years (body-weight 10 – 15 kg): 30mg once daily for 10 days for post-exposure prophylaxis; for up to 6 weeks during an epidemic. Child 1 – 12 years (body-weight 15 – 23kg): 45mg once daily for 10 days for post-exposure prophylaxis; for up to 6 weeks during an epidemic. Child 1 – 12 years (body-weight 23 – 40kg): 60mg once daily for 10 days for post-exposure prophylaxis; for up to 6 weeks during an epidemic. Child 1 – 12 years (body-weight 40 kg and above): 75mg once daily for 10 days for post-exposure prophylaxis; for up to 6 weeks during an epidemic. Child 13 – 17 years: 75mg once daily for 10 days for post-exposure prophylaxis; for up to 6 weeks during an epidemic. Adult: 75mg once daily for 10 days for post-exposure prophylaxis; for up to 6 weeks during an epidemic.
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  • Respiratory Drugs, Omalizumab
    Dosage form: Injection
    Strength: 750mg
    Indications/Special comments: Prophylaxis of severe persistent allergic asthma. Add-on therapy for chronic spontaneous urticaria in patients who have had an inadequate response to H1 antihistamine treatment.
    Dosage Administration: Prophylaxis of severe persistent allergic asthma: By subcutaneous injection: Adult: Dose according to immunoglobulin E concentration and body-weight (consult product literature).Add-on therapy for chronic spontaneous urticaria in patients who have had an inadequate response to H1 antihistamine treatment: By subcutaneous injection: Adult: 300mg every 4 weeks
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  • Ophthalmics - Antiallergies, diagnostics and miscellaneous agents, Olopatadine
    Dosage form: Eye Drop
    Strength: 0.2% drops
    Indications/Special comments: Seasonal allergic conjunctivitis
    Dosage Administration: Seasonal allergic conjunctivitis: To the eye: Child 3 – 17 years: Use 1 drop twice daily (6 - 8 hours between doses) for maximum 4 months.Instill 1 drop twice daily for maximum 4 months.
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  • Obstetric and Gynaecological Medications, Oxytocin
    Dosage form: Injection
    Strength: 10units/ml 1ml ampoules, 20u/2ml (in Lactated Ringers)
    Indications/Special comments: For nonselective induction of labour for medical reasons and for stimulation or reinforcement of labour in patients with dysfunctional inertia. Parenteral oxytocin is also indicated for management of incomplete or therapeutic abortion, as well as to produce uterine contractions during the third stage of labour. Oxytocin is also indicated to control postpartum bleeding or hemorrhage.
    Dosage Administration: Adult: Induction or stimulation of labour: IV infusion: initially at an initial rate 0.5 to 4 milliunits (0.0005 to 0.004 unit) per minute, and then increased gradually at intervals every 20 - 60 minutes in increments of 1 to 2 milliunits (0.001 - 0.002 unit) per minute until a contraction pattern similar to that of normal labour is obtained. The rate of up to 6 milliunits per minute is reported to produce plasma oxytocin concentrations comparable to those in natural labour but doses of up to 20 milliunits (0.02 units) or more per minute may be required. The rate may be reduced gradually once labour is induced. Incomplete or therapeutic abortion: IV infusion: 10 units at a rate of 20 to 40 milliunits (0.02 to 0.04 units) per minute. Control of postpartum uterine bleeding: IV infusion: 10 units at a rate of 20 to 40 milliunits per minute following delivery of the infant(s) and preferably placenta(s). A rate of 20 - 100 milliunits per minute may be used following abortion.
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  • Nasal and Oropharyngeal Preparations, Olopatadine
    Dosage form: Nasal spray
    Strength: 665mcg
    Indications/Special comments: Seasonal allergic rhinitis
    Dosage Administration: Usual Adult Dose for Allergic Rhinitis: Seasonal allergic rhinitis: two sprays in each nostril twice a day. Usual Paediatric Dose for Allergic Rhinitis: Seasonal allergic rhinitis: 12 yrs and older: two sprays in each nostril twice a day.
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  • Miscellaneous Drugs, Oxybutynin
    Dosage form: Tablet
    Strength: 5mg
    Indications/Special comments: Nocturnal enuresis associated with overactive bladder. Urinary frequency. Urinary urgency. Urinary incontinence. Neurogenic bladder instability
    Dosage Administration: Urinary urgency; Urinary incontinence; Neurogenic bladder instability: Orally using immediate-release medicines: Child 5 – 11 years: Initially 2.5 – 3mg twice daily, (by mouth using immediate-release medicines) increased to 5mg 2 – 3 times a day. Child 12 – 17 years: Initially 5mg 2 – 3 times a day, (by mouth) increased if necessary up to 5mg 4 times a day. Adult: Initially 5mg 2 – 3 times a day, (by mouth) increased if necessary up to 5mg 4 times a day. Elderly: Initially 2.5 – 3mg twice daily, (by mouth using immediate-release medicines) increased if tolerated to 5mg twice daily, adjusted according to response. Orally using modified-release tablets: Child 5 – 17 years: Initially 5mg once daily, (by mouth) adjusted in steps of 5mg every 1 week, adjusted according to response; maximum 15mg per day. Adult: Initially 5mg once daily, (by mouth) increased in steps of 5mg every 1 week, adjusted according to response; maximum 20mg per day. Nocturnal enuresis associated with overactive bladder: Orally using immediate-release medicines: Child 5 – 17 years: 2.5 – 3mg twice daily, increased SA to 5mg 2–3 times a day, last dose to be taken before bedtime. Initially by mouth using modified-release tablets. Child 5 – 17 years: Initially 5mg once daily, (by mouth) adjusted in steps of 5mg every 1 week, adjusted according to response; maximum 15mg per day.
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  • Gastrointestinal System Agents, Omeprazole
    Dosage form: Capsule
    Strength: 20mg
    Indications/Special comments: Management of gastric and duodenal ulcers, reflux ooesphagitis and Zollinger Ellison syndrome; also eradication of H. Pylori in combination with appropriate antibiotics
    Dosage Administration: Oral: Adult: Active duodenal ulcer: 20mg/day for 4 - 8 weeks. Gastric ulcers: 40mg/day for 4 - 8 weeks. NSAID-associated erosions: 20mg daily for 4 - 8 weeks. Prevention, 20mg daily. Eradication of H. pylori: 20mg twice daily or 40mg once daily for 7 - 14 days in combination with appropriate antibiotics (clarithromycin 500mg twice daily, amoxicillin 1g twice daily, or as an alternative amoxicillin 1g twice daily, metronidazole 500mg (or tinidazole 500mg twice daily). Zollinger-Ellison Syndrome: initially 60mg once daily; dosage range 20 - 120mg/day, with doses over 80mg given in 2 divided doses. Child: Severe ulcerative reflux oesphagitis: 10 - 20kg, 10mg once daily, increased to 20mg daily if necessary; over 20kg, 20mg once daily, increased to 40mg daily if necessary. Note: Taking the medication at least 1 hour before a meal will have maximum benefit.
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  • Drugs for Correcting Water Electrolyte and Acidbase Disturbances, Oral Rehydration Salt
    Dosage form: Crystals
    Strength: Each sachet: Sodium Chloride 3.5g/litre; Trisodium Citrate Dihydrate 2.9g/litre; Potassium Chloride 1.5g/litre; Glucose 20.0g/litre
    Indications/Special comments: For the prevention and treatment of mild to moderate dehydration, particularly dehydration from acute diarrhoea of any cause, in all age group.
    Dosage Administration: Orally (by cup and spoon in young children): Dissolve one sachet of ORS in 1 liter of water. Do not boil the prepared solution. Discard any remaining solution after 24 hours. Prevention of dehydration: In diarrhoea without signs of dehydration, after each loose stool: Less than 2 years, give 50 - 100ml (1 - 2 small coffee cups); 2 - 10 year, 100 - 200ml (2 - 4 small coffee cups). Treatment of diarrhoea: In diarrhoea with moderate dehydration: 75ml of ORS solution per Kg of body weight in 4 - 6 hours. Repeat if dehydration persists. See package inserts for detailed dosage instructions.
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  • Anxiolytics, Sedatives, Hypnotics and Antipsychotics, Olanzapine
    Dosage form: Tablet
    Strength: 5mg
    Indications/Special comments: Schizophrenia
    Dosage Administration: Oral: Adult: initially 5 - 10mg once daily. Usual therapeutic dose, 10mg.
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