• Anxiolytics, Sedatives, Hypnotics and Antipsychotics, Hydroxyzine Hydrochloride
    Dosage form: Capsule
    Strength: 25mg
    Indications/Special comments: Treatment of anxiety, preoperative sedation, antiemetic, antipruritic. May be combined with opioid analgesics.
    Dosage Administration: Adults: Antianxiety: 25 – 100mg 4 times/day, not to exceed 600mg/day. Preoperative sedation: 50 – 100mg single dose. Antipruritic: 25mg 3 – 4 times daily. Children: 2mg/kg/day divided every 6 – 8 hr.
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  • Anxiolytics, Sedatives, Hypnotics and Antipsychotics, Haloperidol Decanoate
    Dosage form: Injection
    Strength: 50mg/ml, 100mg/ml
    Indications/Special comments: Maintenance in schizophrenia and other psychoses.
    Dosage Administration: Adult: Deep I.M injection: initially 50mg every 4 weeks, if necessary increasing by 50mg increments to 300mg every 4 weeks; higher doses may be needed in some patients; Elderly: initially 12.5 - 25mg every 4 weeks.
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  • Anxiolytics, Sedatives, Hypnotics and Antipsychotics, Haloperidol
    Dosage form: Tablet
    Strength: 0.5mg, 1mg, 2mg, 5mg
    Indications/Special comments: Acute and chronic psychotic disorders including: schizophrenia, manic states, and drug-induced psychoses. Patients with schizophrenia who require long-term parenteral (IM) antipsychotic therapy. Also useful in managing aggressive or agitated patients. Tourette's syndrome. Severe behavioural problems in children which may be accompanied by: unprovoked, combative, explosive hyperexcitability, hyperactivity accompanied by conduct disorders (short-term use when other modalities have failed). Considered second-line treatment after failure with atypical antipsychotic.
    Dosage Administration: Adults: 0.5 – 5mg 2 – 3 times daily. Patients with severe symptoms may require up to 100mg/day. Geriatric Patients or Debilitated Patients: 0.5 – 2mg twice daily initially; may be gradually as needed.
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  • Anxiolytics, Sedatives, Hypnotics and Antipsychotics, Haloperidol
    Dosage form: Suspension
    Strength: 2mg/ml
    Indications/Special comments: Acute and chronic psychotic disorders including: schizophrenia, manic states, and drug-induced psychoses. Patients with schizophrenia who require long-term parenteral (IM) antipsychotic therapy. Also useful in managing aggressive or agitated patients. Tourette's syndrome. Severe behavioural problems in children which may be accompanied by: unprovoked, combative, explosive hyperexcitability, hyperactivity accompanied by conduct disorders (short-term use when other modalities have failed). Considered second-line treatment after failure with atypical antipsychotic.
    Dosage Administration: Children 3 – 12 yr or 15 – 40 kg: 0.25 – 0.5mg/day given in 2 – 3 divided doses; increase by 0.25 – 0.5g every 5 – 7 days; maximum dose: 0.15mg/kg/day (up to 0.75mg/kg/day for Tourette's syndrome or 0.15mg/kg/day for psychoses).
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  • Anxiolytics, Sedatives, Hypnotics and Antipsychotics, Haloperidol
    Dosage form: Injection
    Strength: 5mg/ml
    Indications/Special comments: Acute and chronic psychotic disorders including: schizophrenia, manic states, and drug-induced psychoses. Patients with schizophrenia who require long-term parenteral (IM) antipsychotic therapy. Also useful in managing aggressive or agitated patients. Tourette's syndrome. Severe behavioural problems in children which may be accompanied by: unprovoked, combative, explosive hyperexcitability, hyperactivity accompanied by conduct disorders (short-term use when other modalities have failed). Considered second-line treatment after failure with atypical antipsychotic.
    Dosage Administration: IM: Adults: 2 – 5mg every 1 – 8 hr (not to exceed 100mg/day). Children 6 – 12 yr: 1 – 3 mg/dose every 4 – 8 hours to a maximum of 0.15mg/kg/day. IV: Adults: 0.5 – 5mg may be repeated every 30 min (unlabeled).
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  • Antineoplastics and Related Agents, Hyroxyurea
    Dosage form: Capsule
    Strength: 500mg
    Indications/Special comments: Treatment of metastatic disease, chronic myeloid leukaemia, haemoglobinopathies including sickle cell disease and tumours of the head and neck, an adjunct to nucleoside reverse transcriptase inhibitor in the treatment of HIV disease.
    Dosage Administration: (Refer to individual protocols): Adult: Solid tumours: Intermittent therapy: 80mg/kg as a single dose every third day. Continuous therapy: 20 - 30mg/kg/day given as a single dose/day. Concomitant therapy with irradiation: 80mg/kg as a single dose every third day starting at least 7 days before initiation of irradiation. Resistant chronic myelocytic leukemia: Continuous therapy: 20 - 30mg/kg as a single daily dose. HIV (in combination with ARV agents): 1000 - 1500mg daily in a single dose or divided doses. Sickle cell anaemia: Initial: 15mg/kg/day, increased by 5mg/kg every 12 weeks if blood counts are in an acceptable range until the maximum tolerated dose of 35mg/kg/day is achieved.
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  • Antineoplastics and Related Agents, Hydroxychloroquine Sulphate
    Dosage form: Tablet
    Strength: 200mg
    Indications/Special comments: Inhibits protein synthesis in susceptible organisms by inhibiting DNA and RNA polymerase.
    Dosage Administration: Rheumatoid Arthritis: Adults: 400 – 600mg once daily initially, maintenance 200 – 400mg/day divided 1 – 2 times/day. Children: 3 – 5mg/kg/day divided 1 – 2 times/day to a maximum of 400mg/day; not to exceed 7mg/kg/day. Systemic Lupus Erythematosus:Adults: 400mg once or twice daily, maintenance 200 – 400mg/day. Children: 3 – 5mg/kg/day divided 1 – 2 times/day to a maximum of 400mg/day; not to exceed 7mg/kg/day.
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  • Anti-inflammatory Agents, Hyaluronidase
    Dosage form: Powder for Injection
    Strength: 1500 units
    Indications/Special comments: Enhance permeation of subcutaneous or intramuscular injections, local anaesthetics and subcutaneous infusions; promote resorption of excess fluids and blood.
    Dosage Administration: SC or IM: 1500 units dissolved directly in solution to be injected (ensure compatibility). With local anaesthetics: 1500 units mixed with local anaesthetic solution (ophthalmology, 15 units/mL). Hypodermoclysis: 1500 units dissolved in 1mL water for injections or 0.9% sodium chloride Injection: administered before start of 500 - 1000mL infusion fluid. Extravasation or haematoma: 1500 units dissolved in 1mL water for injections or 0.9% sodium chloride injection, infiltrated into affected area (as soon as possible after extravasation).
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  • Antihistamines and Antiallergics, Hydrocortisone
    Dosage form: Injection
    Strength: 100mg, 250mg, 500mg (preservative free)
    Indications/Special comments: Used for life-threatening shock only after less toxic therapies have proven ineffective.
    Dosage Administration: Adult: for life threatening shock: IV-massive dose 50mg/kg initially and repeated in 4 hours and/or every 24 hours if needed, or 0.5 - 2g IV initially and repeated at 2 to 6 hours intervals as required
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  • Analgesic/Antipyretic/Anti-inflammatory, Hydrocodone + Acetaminophen
    Dosage form: Tablet
    Strength: 5mg + 500mg
    Indications/Special comments: Management of pain that is severe enough to warrant daily, around-the-clock, long-term opioid treatment where alternative treatment options are inadequate. Combination products: Management of moderate to severe pain. Antitussive (usually in combination products with decongestants).
    Dosage Administration: Adults: Analgesic– 2.5 – 10mg every 3 – 6 hr as needed; if using combination products, acetaminophen dosage should not exceed 4g/day and should not exceed 5 tablets/day of ibuprofen-containing products; Antitussive– 5mg every 4 – 6 hr as needed;
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