Drug Class: Anaesthetic, General
Dosage Form: Injection
Strength: 10mg/ml in 20ml ampoule, 1g/100ml
Indications/Special comments: Intravenous anaesthesia (both induction and maintenance).
Dosage Administration: Induction: Slow IV injection or infusion, titrated against the response obtained from 40mg every 10 seconds. Most adult patients under 55 years require 1.5 - 2.5mg/kg. Maintenance: continuous infusion, the rate varying from 4 - 12mg/kg/hour. Alternatively, a technique of repeat bolus injections may be used: increments of 25 - 50mg may be given at intervals determined by clinical signs of lightening anaesthesia (usually every 6 minutes). *Patients over 55 years and high-risk patients may require less than the usual doses. For induction: 1 - 1.5mg/kg may be adequate. Maintenance: 2 - 6mg/kg hour. Child: over 3 years: Induction: 2.5mg/kg adjusted as necessary. Maintenance: IV infusion, 9 - 15mg/kg/hour.