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Verapamil Hydrochloride

Drug Class: Cardiovascular Drugs
Dosage Form: Capsule ER
Strength: 120mg, 180mg, 240mg
Indications/Special comments: Angina, paroxysmal supraventricular arrhythmias, atrial fibrillation and hypertension.
Dosage Administration: Essential Hypertension: The dose of verapamil hydrochloride extended-release capsules should be individualized by titration. The usual daily dose of extended-release verapamil hydrochloride capsules in clinical trials has been 240 mg given by mouth once daily in the morning. However, initial doses of 120 mg a day may be warranted in patients who may have an increased response to verapamil (e.g., elderly, small people, etc.). Upward titration should be based on therapeutic efficacy and safety evaluated approximately 24 hours after dosing. The antihypertensive effects of verapamil hydrochloride extended-release capsules are evident within the first week of therapy. If adequate response is not obtained with 120 mg of verapamil hydrochloride extended-release capsules, the dose may be titrated upward in the following manner: 180 mg in the morning, 240 mg in the morning, 360 mg in the morning, 480 mg in the morning. Verapamil extended-release capsules are for once a day administration. When switching from immediate-release verapamil to verapamil hydrochloride extended-release capsules, the same total daily dose of verapamil hydrochloride extended-release capsules can be used. As with immediate-release verapamil, dosages of verapamil hydrochloride extended-release capsules should be individualized and titration may be needed in some patients.